Cystic Fibrosis Research Today is a free monthly online journal that collates and summarizes the latest research about Cystic Fibrosis, including details on symptoms, genetics, treatment, information.

Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis.

Husson MO, Wizla-Derambure N, Turck D, Gosset P, Wallaert B

EA 3925, Laboratoire de Bactériologie-Hygiène, Hôpital Calmette, Boulevard du Professeur J. Leclercq, Lille, France. mohusson@chru-lille.fr

OBJECTIVES: The aim of this study was to evaluate the anti-inflammatory properties of intermittent inhaled tobramycin. METHODS: To establish this, we initiated a prospective study to measure the concentration of the three pro-inflammatory cytokines IL-8, IL-6 and TNF-alpha in the sputum from 20 cystic fibrosis (CF) patients (15 teenagers and 5 young adults) during cycles and off cycles. RESULTS: A significant decrease in IL-8 (P = 0.001) and a more moderate decrease in IL-6 (P = 0.046) and TNF-alpha (P = 0.052) levels were observed during cycles, even if no significant decrease in the number of leucocytes was observed. CONCLUSIONS: These results associated with a decrease in the Pseudomonas aeruginosa population can contribute in part to the beneficial effect of intermittent inhaled tobramycin on pulmonary function.

Published 22 July 2005 in J Antimicrob Chemother, 56(1): 247-9.
Full-text of this article is available online (may require subscription).

© 2004-2008 Cystic Fibrosis Research Today. All Rights Reserved.