Cystic Fibrosis Research Today is a free monthly online journal that collates and summarizes the latest research about Cystic Fibrosis, including details on symptoms, genetics, treatment, information.

Cyclosporine-related neurotoxicity in a patient after bilateral lung transplantation for cystic fibrosis.

Lischke R, Simonek J, Stolz AJ, Schützner J, Belsan T, Marusic P, Pafko P

3rd Department of Surgery, University Hospital Motol, Prague, Czech Republic. rlischke@hotmail.com

Cyclosporine (CsA) is a widely used immunosuppressant following solid organ transplantation. CsA administration is associated with a number of systemic complications, including neurotoxicity. A 33-year-old man with cystic fibrosis, who underwent bilateral lung transplantation, presented with severe neurotoxic symptoms leading to coma in association with CsA administration combined with high doses of methylprednisolone for treatment of an acute rejection episode. After discontinuation of CsA, a quick resolution of his clinical status was observed, as well as of the pathological findings on magnetic resonance imaging (MRI). CsA was replaced with tacrolimus leading to an uneventful course.

Published 28 December 2004 in Transplant Proc, 36(9): 2837-9.
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