Cystic Fibrosis Research Today is a free monthly online journal that collates and summarizes the latest research about Cystic Fibrosis, including details on symptoms, genetics, treatment, information.

Variability of markers of inflammation and infection in induced sputum in children with cystic fibrosis.

Ordoñez CL, Kartashov AI, Wohl ME

Department of Medicine and Clinical Research Program, Children's Hospital Boston, Massachusetts 02115, USA. claudia.ordonez@childrens.harvard.edu

To determine reproducibility of inflammatory marker concentrations in induced sputum from subjects with cystic fibrosis (CF), 15 nonexpectorating children, 6 to 13 years of age with mild CF lung disease, underwent 3 weekly sputum inductions with 3% saline. Neutrophil elastase concentration and bacterial cultures were reproducible. This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction.

Published 2 November 2004 in J Pediatr, 145(5): 689-92.
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